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BCR-ABL1 tyrosine kinase activity at diagnosis, as determined via the pCrkL/CrkL ratio, is predictive of clinical outcome in chronic myeloid leukaemia.

作者信息

Lucas Claire M, Harris Robert J, Giannoudis Athina, Knight Katy, Watmough Sarah J, Clark Richard E

出版信息

Br J Haematol. 2010 May;149(3):458-60. doi: 10.1111/j.1365-2141.2009.08066.x. Epub 2010 Jan 11.

DOI:10.1111/j.1365-2141.2009.08066.x
PMID:20067558
Abstract
摘要

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1
BCR-ABL1 tyrosine kinase activity at diagnosis, as determined via the pCrkL/CrkL ratio, is predictive of clinical outcome in chronic myeloid leukaemia.通过pCrkL/CrkL比率测定的诊断时BCR-ABL1酪氨酸激酶活性可预测慢性髓性白血病的临床结局。
Br J Haematol. 2010 May;149(3):458-60. doi: 10.1111/j.1365-2141.2009.08066.x. Epub 2010 Jan 11.
2
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[Molecular monitoring: an essential component of the treatment for chronic myeloid leukemia].
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Active (p)CrkL is overexpressed in human malignancies: potential role as a surrogate parameter for therapeutic tyrosine kinase inhibition.活性(p)CrkL在人类恶性肿瘤中过表达:作为治疗性酪氨酸激酶抑制替代参数的潜在作用。
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RQ-PCR based WT1 expression in comparison to BCR-ABL quantification can predict Philadelphia negative clonal evolution in patients with imatinib-treated chronic myeloid leukaemia.基于 RQ-PCR 的 WT1 表达与 BCR-ABL 定量相比,可以预测伊马替尼治疗的慢性髓性白血病患者中费城染色体阴性克隆进化。
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A half-log increase in BCR-ABL RNA predicts a higher risk of relapse in patients with chronic myeloid leukemia with an imatinib-induced complete cytogenetic response.在接受伊马替尼治疗获得完全细胞遗传学缓解的慢性髓性白血病患者中,BCR-ABL RNA水平升高半对数预示着更高的复发风险。
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Adverse outcomes for chronic myeloid leukemia patients with splenomegaly and low in vivo kinase inhibition on imatinib.伴有巨脾和伊马替尼体内激酶抑制率低的慢性髓性白血病患者的不良结局。
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在慢性髓性白血病原代白细胞中成功保存天然BCR::ABL1显示激酶活性降低。
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Lab Chip. 2020 Mar 3;20(5):942-948. doi: 10.1039/c9lc01213c.
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Second generation tyrosine kinase inhibitors prevent disease progression in high-risk (high CIP2A) chronic myeloid leukaemia patients.第二代酪氨酸激酶抑制剂可预防高危(高 CIP2A)慢性髓性白血病患者的疾病进展。
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