Schilling Thomas F, Le Pabic Pierre
Department of Developmental and Cell Biology, 4462 Natural Sciences II, University of California, Irvine, CA 92697-2300, USA.
J Biol. 2009;8(11):101. doi: 10.1186/jbiol205. Epub 2009 Dec 22.
Zebrafish are a powerful system for studying the early embryonic events that form the skull and face, as a model for human craniofacial birth defects such as cleft palate. Signaling pathways that pattern the pharyngeal arches (which contain skeletal precursors of the palate, as well as jaws and gills) are discussed in light of a recent paper in BMC Developmental Biology on requirements for Hedgehog signaling in craniofacial development.
斑马鱼是研究形成头骨和面部的早期胚胎事件的强大系统，可作为人类颅面出生缺陷（如腭裂）的模型。根据《BMC发育生物学》上最近一篇关于刺猬信号通路在颅面发育中的需求的论文，讨论了形成咽弓（其中包含腭、颌骨和鳃的骨骼前体）的信号通路。
