Decousus H, Boissier C, Perpoint B, Page Y, Mismetti P, Laporte S, Tardy B, Queneau P
Department of Clinical Pharmacology, Bellevue Hospital, Saint-Etienne, France.
Ann N Y Acad Sci. 1991;618:159-65. doi: 10.1111/j.1749-6632.1991.tb27244.x.
Arterial thromboembolic disorders are the leading cause of death in most of the advanced nations. The study of epidemiologic relationship of these disorders to biological rhythms may lead to a better understanding and perhaps a better treatment. Chronoepidemiologic studies demonstrated a morning peak for arterial thromboembolic disorders (cerebral and myocardial infarctions) and sudden cardiac deaths. These variations might be explained partially by circadian variations in hemostasis. Indeed chronophysiologic studies have shown that hemostatic variables follow circadian rhythms. The level of platelet aggregation and that of blood coagulation have been found to be increased in the morning whereas fibrinolytic activity is lower at this time of the day. The facts suggest a chronotherapeutic approach in thromboembolic disorders.
动脉血栓栓塞性疾病是大多数发达国家的主要死因。对这些疾病与生物节律之间流行病学关系的研究可能会带来更好的理解，或许还能有更好的治疗方法。时间流行病学研究表明，动脉血栓栓塞性疾病（脑梗死和心肌梗死）及心源性猝死存在早晨高峰。这些变化可能部分由止血的昼夜变化来解释。事实上，时间生理学研究已表明，止血变量遵循昼夜节律。已发现早晨血小板聚集水平和血液凝固水平会升高，而一天中的这个时段纤溶活性较低。这些事实提示在血栓栓塞性疾病中采用时间治疗方法。
