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作为药物载体的前体脂质体

Proniosomes as drug carriers.

作者信息

Sankar V, Ruckmani K, Durga S, Jailani S

机构信息

Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore-641004.

出版信息

Pak J Pharm Sci. 2010 Jan;23(1):103-7.

Abstract

Approaches to stabilize niosomal drug delivery system without affecting its properties of merits have resulted in the development of the promising drug carrier, proniosomes. Proniosomes is dry formulation using suitable carrier coated with non ionic surfactants and can be converted into niosomes immediately before use by hydration. These proniosome-derived niosomes are as good as or even better than conventional niosomes. The focus of this review is to bring out different aspects related to proniosomes preparation, characterization, entrapment efficiency, in vitro drug release, applications and merits.

摘要

在不影响其优点特性的情况下稳定非离子型脂质体药物递送系统的方法,促成了有前景的药物载体——前体脂质体的开发。前体脂质体是一种干燥制剂,使用涂有非离子表面活性剂的合适载体,在使用前通过水合作用可立即转化为脂质体。这些源自前体脂质体的脂质体与传统脂质体一样好,甚至更好。本综述的重点是阐述与前体脂质体制备、表征、包封效率、体外药物释放、应用及优点相关的不同方面。

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