School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, 310013, China.
Department of Pharmacy, Jin Hua Municipal Maternal and Child Health Care Hospital, Jinhua, Zhejiang, 321000, China.
Drug Deliv. 2023 Dec;30(1):2175925. doi: 10.1080/10717544.2023.2175925.
Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants are drugs that can inhibit the body's immune response. Considering drug side effects such as hepatorenal toxicity and the unique structure of the eye, incorporating immunosuppressants into ophthalmic nanodrug delivery systems, such as microparticles, nanoparticles, liposomes, micelles, implants, and gels, has the advantages of improving solubility, increasing bioavailability, high eye-target specificity, and reducing side effects. This study reviews recent research and applications of this aspect to provide a reference for the development of an ophthalmic drug delivery system.
免疫眼病是一组自身免疫性眼病。免疫抑制剂是能够抑制机体免疫反应的药物。考虑到肝肾功能毒性等药物副作用以及眼部的独特结构，将免疫抑制剂纳入眼科纳米药物递送系统，如微球、纳米粒、脂质体、胶束、植入物和凝胶中，具有提高溶解度、增加生物利用度、高眼靶向特异性和降低副作用的优点。本研究综述了这方面的最新研究进展和应用，为眼科药物递送系统的开发提供参考。
