Department of Pathology, University of California at San Diego, 214 Dickinson Street, San Diego, CA 92103-8416, USA.
J Antimicrob Chemother. 2010 Mar;65(3):531-4. doi: 10.1093/jac/dkp501. Epub 2010 Jan 12.
Attachment to the small intestinal mucosa is crucial for initiating and maintaining Giardia infection. We tested the effect of isoflavones on Giardia attachment.
We evaluated the effect of formononetin on trophozoite attachment to glass, to intestinal epithelial cell layers in vitro and to murine small intestinal explants, and on the intestinal load in mice.
We found that the isoflavone formononetin inhibits both attachment and flagellar motility within minutes and reduces the trophozoite load of Giardia in mice within 1.5 h after treatment.
The antigiardial activity of formononetin is at least partially due to its capacity to rapidly detach trophozoites.
与小肠黏膜的附着对于启动和维持贾第虫感染至关重要。我们测试了异黄酮对贾第虫附着的影响。
我们评估了芒柄花素对滋养体附着到玻璃、体外肠上皮细胞层和小鼠小肠外植体的影响，以及对小鼠肠道负荷的影响。
我们发现异黄酮芒柄花素在数分钟内抑制附着和鞭毛运动，并在治疗后 1.5 小时内降低小鼠体内贾第虫的滋养体负荷。
芒柄花素的抗贾第虫活性至少部分归因于其快速分离滋养体的能力。
