慢性淋巴细胞白血病中免疫球蛋白重链可变区基因的使用和（超）抗原驱动。
Immunoglobulin heavy chain variable gene usage and (super)-antigen drive in chronic lymphocytic leukemia.
机构信息
University of Ulm, Department of Medicine III, Ulm, Germany.
出版信息
Clin Cancer Res. 2010 Jan 15;16(2):373-5. doi: 10.1158/1078-0432.CCR-09-2948. Epub 2010 Jan 12.
Abstract
Increasing evidence supports the prognostic relevance of specific immunoglobulin heavy chain variable (IGHV) genes or stereotyped B-cell receptors (BCR) in chronic lymphocytic leukemia (CLL). The clonotypic BCRs differ in their specificity and affinity toward classical antigens and/or superantigens. The BCR-triggered mechanisms are distinct but could explain in part the different clinical behavior among CLL subgroups.
摘要
越来越多的证据支持特定免疫球蛋白重链可变（IGHV）基因或定型 B 细胞受体（BCR）在慢性淋巴细胞白血病（CLL）中的预后相关性。克隆型 BCR 在其对经典抗原和/或超抗原的特异性和亲和力方面存在差异。BCR 触发的机制是不同的，但可以部分解释 CLL 亚组之间不同的临床行为。
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