幼兔血管化复合下颌骨同种异体移植物的生长

Growth of vascularized composite mandibular allografts in young rabbits.

作者信息

Randzio J, Kniha H, Gold M E, Chang T T, Su L D, Park H H, Cho J S, Booth K, Furnas D W

机构信息

Division of Plastic Surgery, University of California, Irvine.

出版信息

Ann Plast Surg. 1991 Feb;26(2):140-8. doi: 10.1097/00000637-199102000-00006.

DOI:10.1097/00000637-199102000-00006

PMID:2006840

Abstract

Forty-one hemimandible allografts were transplanted in young rabbits immunosuppressed with cyclosporine. The majority of the grafts demonstrated normal wound healing, and growth of hair, bone, and teeth. The mandibular body and the premolars showed significant growth in length. The allografted mandibles functioned sufficiently that the rabbits took oral nourishment soon after surgery. Long-term survival was limited by a toxic "wasting syndrome" specific for rabbits under treatment with cyclosporine.

摘要

将41个半侧下颌骨异体移植物移植到用环孢素免疫抑制的幼兔体内。大多数移植物显示出正常的伤口愈合以及毛发、骨骼和牙齿的生长。下颌体和前磨牙的长度有显著增长。异体移植的下颌骨功能良好，兔子在手术后不久就能摄取口服营养。长期存活受到环孢素治疗下兔子特有的毒性“消瘦综合征”的限制。