Advanced prosthetic valve endocarditis is often associated with substantial destruction of the tissues adjacent to the prosthesis. Removal of the infected prosthesis and débridement of the infected tissues make implantation of a new prosthesis challenging. Herein, we discuss successful surgical aortic valve translocation in a 50-year-old man who had advanced acute prosthetic valve endocarditis with destruction of the aortic annulus. One year after being discharged from the hospital, the patient was asymptomatic with good exercise tolerance.