Ferreira-Cravo Marlize, Welker Alexis F, Hermes-Lima Marcelo
Oxyradical Research Group, Departamento de Biologia Celular, Universidade de Brasília, Brasília, DF, 70910-900, Brazil.
Prog Mol Subcell Biol. 2010;49:47-61. doi: 10.1007/978-3-642-02421-4_3.
In situations of food and water deprivation associated with unfavorable environmental conditions, a number of animal species undergo estivation. This state of locomotor inactivity involves a drastic reduction in the metabolic rate, allowing the estivator to survive long periods of adverse situations. However, the arousal from dormancy causes a rapid increase in oxygen consumption, which may elevate the production of oxygen radicals. Thus, it is expected that animals that arouse from estivation suffer a physiological oxidative stress. The reported mechanisms that protect estivators (anurans and gastropods) from the potential dangers of increased oxyradical formation are discussed. This includes the modulation of endogenous antioxidant defenses (enzymes and glutathione) of gastropods during dormancy, preparing them for arousal. A different strategy used for estivating anurans is also discussed.
在与不利环境条件相关的食物和水匮乏的情况下，许多动物物种会进行夏眠。这种运动不活跃的状态涉及代谢率的急剧降低，使夏眠动物能够在长期的不利情况下存活。然而，从休眠中苏醒会导致氧气消耗迅速增加，这可能会提高氧自由基的产生。因此，可以预期从夏眠中苏醒的动物会遭受生理氧化应激。本文讨论了已报道的保护夏眠动物（无尾两栖类和腹足纲动物）免受氧自由基形成增加的潜在危险的机制。这包括在休眠期间对腹足纲动物内源性抗氧化防御（酶和谷胱甘肽）的调节，为它们的苏醒做好准备。还讨论了无尾两栖类动物用于夏眠的另一种策略。
