Kirshon B, Moise K J, Mari G, Willis R
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030.
Am J Perinatol. 1991 Mar;8(2):86-8. doi: 10.1055/s-2007-999349.
Four quadrant quantitative amniotic fluid volume (length, width, and depth) was performed in six fetuses prior to and during indomethacin therapy for preterm labor in patients with normal amniotic fluid volume prior to therapy. The dose of indomethacin was 25 mg orally every 6 hours. One patient had to have the dose reduced to 25 mg every 12 hours due to constriction of the ductus arteriosus. Fetal urine output was determined prior to and during indomethacin therapy. The mean pretherapy amniotic fluid volume of 341.5 +/- 43.2 mm declined to 97 +/- 9.3 mm at the time of discontinuation of indomethacin for oligohydramnios. This occurred after 15 days of 25 mg indomethacin orally every 6 hours in four patients and after 28 days at 25 mg indomethacin every 12 hours in the remaining patient. Fetal urine output prior to and following indomethacin was 4.93 +/- 14 ml and 1.73 +/- 0.6 ml/hr, respectively. Prolonged indomethacin therapy results in decreased fetal urine output with resultant oligohydramnios and appears to be the major limiting factor aside from ductal constriction to long-term indomethacin therapy.
在对治疗前羊水体积正常的患者进行吲哚美辛治疗早产期间及治疗前，对6例胎儿进行了四象限羊水定量（测量长度、宽度和深度）。吲哚美辛的剂量为口服25毫克，每6小时一次。1例患者因动脉导管狭窄，不得不将剂量减至每12小时25毫克。在吲哚美辛治疗期间及治疗前测定胎儿尿量。治疗前羊水平均体积为341.5±43.2毫米，因羊水过少停用吲哚美辛时降至97±9.3毫米。4例患者每6小时口服25毫克吲哚美辛15天后出现这种情况，其余1例患者每12小时口服25毫克吲哚美辛28天后出现这种情况。吲哚美辛治疗前后胎儿尿量分别为4.93±14毫升/小时和1.73±0.6毫升/小时。长期使用吲哚美辛治疗会导致胎儿尿量减少，进而引起羊水过少，这似乎是除导管狭窄外长期使用吲哚美辛治疗的主要限制因素。
