体温会影响小鼠对乙醇及乙醇/戊巴比妥的致死反应。

Body temperature influences ethanol and ethanol/pentobarbital lethality in mice.

作者信息

Finn D A, Syapin P J, Bejanian M, Jones B L, Alkana R L

机构信息

Alcohol and Brain Research Laboratory, School of Pharmacy, University of Southern California, Los Angeles 90033.

出版信息

Alcohol. 1991 Jan-Feb;8(1):39-41. doi: 10.1016/0741-8329(91)91232-q.

DOI:10.1016/0741-8329(91)91232-q

PMID:2006984

Abstract

The effect of body temperature on ethanol (ETOH) or ethanol plus pentobarbital (ETOH/PB) lethality was investigated in C57BL/6J mice. Decreasing ambient temperatures from 35-20 degrees C, decreased rectal temperatures from 38-20 degrees C and increased 8-hour survival from 0-93% for ETOH-treated and from 0-100% for ETOH/PB-treated mice. ETOH and ETOH/PB animals with no hypothermia (body temperatures = 38 degrees C) had the highest lethality. Those with body temperatures between 30-32 degrees C had the highest 24-hour survival. These results suggest that controlled hypothermia may be useful in reducing lethality from ethanol or ethanol/combination overdoses.

摘要

在C57BL/6J小鼠中研究了体温对乙醇（ETOH）或乙醇加戊巴比妥（ETOH/PB）致死率的影响。将环境温度从35℃降至20℃，乙醇处理组小鼠的直肠温度从38℃降至20℃，8小时存活率从0%增至93%；乙醇加戊巴比妥处理组小鼠的直肠温度从38℃降至20℃，8小时存活率从0%增至100%。体温未降低（体温 = 38℃）的乙醇和乙醇加戊巴比妥处理组动物致死率最高。体温在30 - 32℃之间的动物24小时存活率最高。这些结果表明，控制性低温可能有助于降低乙醇或乙醇/组合药物过量导致的致死率。