Fariello R, Boni E, Corda L, Cantalamessa A, Zaninelli A, Pollavini G, Alicandri C, Muiesan G
Department of Internal Medicine, University of Brescia, Italy.
Am J Hypertens. 1991 Jan;4(1 Pt 1):27-33. doi: 10.1093/ajh/4.1.27.
Intraarterial blood pressure (BP) monitoring during free ambulation (Oxford technique) was carried out in 12 essential mild-to-moderate hypertensive patients undergoing 4 weeks treatment with felodipine, 10 mg given once daily in an extended release formulation. Compared to placebo, felodipine significantly reduced systolic and diastolic blood pressure throughout 24 h. The greatest reduction was observed at 10 AM, 3 h after drug administration (-32 +/- 6/-24 +/- 5 mm Hg for systolic and diastolic BP, respectively, P less than .001). Hourly BP values remained significantly lower up to and including the 24th hour during felodipine extended release treatment (-18 +/- 5/-11 +/- 3 mm Hg, P less than .001). Felodipine extended release also reduced 24 h blood pressure variability, evaluated on the standard deviation of each hourly mean (from 16.3 +/- 0.9/12.6 +/- 0.6 to 13.4 +/- 0.6/10.4 +/- 0.6 mm Hg, P less than .01). Furthermore, absolute BP values dropped significantly at the peaks of dynamic exercise (bicycle ergometer: from 248 +/- 13/123 +/- 11 to 204 +/- 24/102 +/- 13 mm Hg, P less than .001), isometric exercise (hand grip: from 232 +/- 18/133 +/- 16 to 180 +/- 20/101 +/- 16 mm Hg, P less than .001), and cold pressor test (from 229 +/- 20/127 +/- 14 to 178 +/- 22/99 +/- 15 mm Hg, P less than .001). In conclusion, felodipine extended release exerts a good antihypertensive effect which is maintained for 24 h and reduces the level of blood pressure peaks reached under different physical stresses.
对12例轻至中度原发性高血压患者采用 felodipine（缓释制剂，每日1次，每次10 mg）进行4周治疗，期间采用牛津技术对患者自由活动时的动脉内血压（BP）进行监测。与安慰剂相比，felodipine 在24小时内显著降低收缩压和舒张压。给药3小时后（上午10点）血压下降幅度最大（收缩压和舒张压分别下降-32±6/-24±5 mmHg，P<0.001）。在 felodipine 缓释治疗期间，直至第24小时，每小时的血压值仍显著降低（-18±5/-11±3 mmHg，P<0.001）。felodipine 缓释制剂还降低了24小时血压变异性，根据每小时平均值的标准差评估（从16.3±0.9/12.6±0.6降至13.4±0.6/10.4±0.6 mmHg，P<0.01）。此外，在动态运动（自行车测力计：从248±13/123±11降至204±24/102±13 mmHg，P<0.001）、等长运动（握力：从232±18/133±16降至180±20/101±16 mmHg，P<0.001）和冷加压试验（从229±20/127±14降至178±22/99±15 mmHg，P<0.001）的峰值时，绝对血压值显著下降。总之，felodipine 缓释制剂具有良好的降压作用，可维持24小时，并降低不同身体应激下达到的血压峰值水平。
