扩张型心肌病患者左心室局部收缩功能及不同步性的实时三维超声心动图评估
Real time three-dimensional echocardiographic assessment of left ventricular regional systolic function and dyssynchrony in patients with dilated cardiomyopathy.
作者信息
Mu Yuming, Chen Lu, Tang Qi, Ayoufu Guligena
机构信息
Department of Echocardiography, First Affiliated Hospital, Xinjiang Medical University, Urmuqi 830000, China.
出版信息
Echocardiography. 2010 Apr;27(4):415-20. doi: 10.1111/j.1540-8175.2009.01028.x. Epub 2010 Jan 11.
PURPOSE
To evaluate left ventricular (LV) regional systolic function and dyssynchrony in patients with dilated cardiomyopathy (DCM) by real time three-dimensional echocardiography (RT-3DE).
METHODS
The study population comprised 30 normal controls (NOR) and 44 patients with DCM. We divided the left ventricle into apical, middle, and basal regions. We calculated the LV regional end-diastolic volume ((R)EDV), regional end-systolic volume ((R)ESV), regional ejection fraction ((R)EF), and standard deviation in the time to minimal systolic volume in each level segment (Tmsv-SD) of the three regions by RT-3DE.
RESULTS
Compared with NOR, the (R)EDV, (R)ESV, and Tmsv-SD of DCM were significantly higher, whereas the (R)EF was lower (P < 0.01). In DCM, the Tmsv-SD increased smoothly from base to apex, and the (R)EF gradually decreased from base to apex (P < 0. 05). Linear correlation was observed between the Tmsv-SD of the middle region and 3D-EF in DCM (r =-0. 6829, P < 0.01).
CONCLUSION
RT-3DE provides a simple and feasible approach to quantify LV regional systolic function and dyssynchrony.
目的
采用实时三维超声心动图（RT-3DE）评估扩张型心肌病（DCM）患者左心室（LV）的局部收缩功能及不同步性。
方法
研究对象包括30名正常对照者（NOR）和44例DCM患者。我们将左心室分为心尖、中间和基底区域。通过RT-3DE计算三个区域每个水平节段的左心室局部舒张末期容积（(R)EDV）、局部收缩末期容积（(R)ESV）、局部射血分数（(R)EF）以及达到最小收缩容积时间的标准差（Tmsv-SD）。
结果
与NOR相比，DCM患者的(R)EDV、(R)ESV和Tmsv-SD显著更高，而(R)EF更低（P<0.01）。在DCM中，Tmsv-SD从基底到心尖平滑增加，(R)EF从基底到心尖逐渐降低（P<0.05）。DCM中间区域的Tmsv-SD与三维射血分数（3D-EF）之间存在线性相关性（r=-0.6829，P<0.01）。
结论
RT-3DE为量化左心室局部收缩功能及不同步性提供了一种简单可行的方法。
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