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癌症治疗中,患者对卡铂联合其他姑息治疗方法的认知。

Owner's perception of carboplatin in conjunction with other palliative treatments for cancer therapy.

作者信息

Bowles D B, Robson M C, Galloway P E, Walker L

机构信息

Veterinary Specialist Group, Carrington Road, Auckland, New Zealand.

出版信息

J Small Anim Pract. 2010 Feb;51(2):104-12. doi: 10.1111/j.1748-5827.2009.00891.x. Epub 2010 Jan 11.

Abstract

OBJECTIVES

To determine owner's perception of their pet's quality of life during treatment with carboplatin for a variety of canine and feline neoplasms.

METHODS

Owners were contacted via a postal questionnaire and asked questions regarding their perception of chemotherapy in pets and their perception of carboplatin treatment in their pet.

RESULTS

Twenty-eight (59%) of owners responded to the questionnaire. Forty-three percent of owners had not considered chemotherapy in pets before treatment; however, after treatment, 89% of owners supported its use. Sixteen (57%) patients had mild to severe side effects. Most patients experienced mild side effects, including lethargy and loss of appetite. Quality of life during treatment was reduced compared with prediagnosis quality of life however at its best was significantly improved compared with pretreatment quality of life. Eighty-nine per cent of respondents did not regret treating their pet.

CLINICAL SIGNIFICANCE

Carboplatin is well tolerated by both owners and pets. Most patients have either no side effects or experience mild lethargy or inappetence. Carboplatin treatment, either alone or in conjunction with other medications, should be considered as a palliative treatment in both dogs and cats with susceptible neoplasms.

摘要

目的

确定在使用卡铂治疗各种犬猫肿瘤期间,宠物主人对其宠物生活质量的看法。

方法

通过邮寄问卷与宠物主人取得联系,询问他们对宠物化疗的看法以及对其宠物卡铂治疗的看法。

结果

28名(59%)宠物主人回复了问卷。43%的宠物主人在治疗前未考虑过对宠物进行化疗;然而,治疗后,89%的宠物主人支持使用化疗。16名(57%)患者出现了轻度至重度的副作用。大多数患者经历了轻度副作用,包括嗜睡和食欲不振。与诊断前的生活质量相比,治疗期间的生活质量有所下降,但与治疗前的生活质量相比,最佳状态时显著改善。89%的受访者不后悔治疗他们的宠物。

临床意义

卡铂在宠物主人和宠物中耐受性良好。大多数患者要么没有副作用,要么经历轻度嗜睡或食欲不振。卡铂治疗,无论是单独使用还是与其他药物联合使用,都应被视为患有易感肿瘤的犬猫的姑息治疗方法。

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