Karimzadeh Mohammad Ali, Ayazi Rozbahani Maryam, Tabibnejad Nasim
Shahid sadoughi University of Medical Sciences, Safaieyeh, Yazd, Iran.
Aust N Z J Obstet Gynaecol. 2009 Dec;49(6):677-80. doi: 10.1111/j.1479-828X.2009.01076.x.
Implantation failure is the most important cause of recurrent in vitro fertilisation (IVF)/intra cytoplasmic sperm injection (ICSI) failure. It has been reported that endometrial injury using a biopsy catheter resulted in a higher pregnancy rate in following cycle of treatment. The local endometrial trauma increases the implantation rate through the release of chemical mediators such as histamine and growth factor.
To evaluate the influence of endometrial biopsy on increasing implantation rate in patients with recurrent implantation failures.
In a randomised control trial study, 115 women each with at least two implantation failures were randomly assigned to two groups. In the case group, endometrial biopsy was obtained from patients in the luteal phase of previous cycle, and implantation and clinical pregnancy rates were compared with those of patients in the control group.
The implantation rate was determined as 10.9% in the biopsy group compared to 3.38% in the controls. The clinical pregnancy rate was significantly higher in the case group than in controls (27.1% and 8.9% respectively).
The results suggest that pregnancy outcome increases through IVF or ICSI after endometrial biopsy.
着床失败是反复体外受精（IVF）/卵胞浆内单精子注射（ICSI）失败的最重要原因。据报道，使用活检导管造成子宫内膜损伤会使后续治疗周期的妊娠率更高。局部子宫内膜创伤通过释放组胺和生长因子等化学介质提高着床率。
评估子宫内膜活检对提高反复着床失败患者着床率的影响。
在一项随机对照试验研究中，将115名至少有两次着床失败的女性随机分为两组。病例组在前一周期的黄体期对患者进行子宫内膜活检，并将着床率和临床妊娠率与对照组患者进行比较。
活检组的着床率为10.9%，而对照组为3.38%。病例组的临床妊娠率显著高于对照组（分别为27.1%和8.9%）。
结果表明，子宫内膜活检后通过IVF或ICSI可改善妊娠结局。
