在接受受精周期的不孕妇女中进行子宫内膜搔刮损伤：系统评价和荟萃分析。

Endometrial scratch injury in infertile women undergoing fertilization cycles: a systematic review and meta-analysis.

机构信息

Department of Obstetrics and Gynecology, Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt.

出版信息

J Int Med Res. 2023 Jul;51(7):3000605231175365. doi: 10.1177/03000605231175365.

OBJECTIVE

This study aimed to evaluate the effect of endometrial scratch injury (ESI) in infertile women undergoing fertilization (IVF).

METHODS

We screened MEDLINE, CENTRAL, EMBASE, Web of Science, and the Cochrane Central Register from inception to April 2023 using keywords related to endometrial scratch, implantation, infertility, and IVF. We included 41 randomized, controlled trials of ESI in IVF cycles (9084 women). The primary outcomes were the clinical pregnancy, ongoing pregnancy, and live birth rates.

RESULTS

The clinical pregnancy rate was reported in all 41 studies. The odds ratio (OR) for the clinical pregnancy rate had an effect estimate of 1.34 with a 95% confidence interval (CI) of 1.14 to 1.58. The live birth rate was reported in 32 studies with 8129 participants. The OR for the live birth rate had an effect estimate of 1.30 with a 95% CI of 1.06 to 1.60. The multiple pregnancy rate was reported in 21 studies with 5736 participants. The OR for the multiple pregnancy rate had an effect estimate of 1.35 with a 95% CI of 1.07 to 1.71.

CONCLUSION

ESI increases the clinical pregnancy, ongoing pregnancy, live birth, multiple pregnancy, and implantation rates in women undergoing IVF cycles.

目的

本研究旨在评估子宫内膜搔刮损伤（ESI）对接受体外受精（IVF）的不孕女性的影响。

方法

我们使用与子宫内膜搔刮、着床、不孕和 IVF 相关的关键词，从建库到 2023 年 4 月，对 MEDLINE、CENTRAL、EMBASE、Web of Science 和 Cochrane 中央注册库进行了筛选，共纳入 41 项关于 IVF 周期中 ESI 的随机对照试验（9084 名女性）。主要结局指标是临床妊娠率、持续妊娠率和活产率。

结果

所有 41 项研究均报告了临床妊娠率。临床妊娠率的优势比（OR）的效应估计值为 1.34，95%置信区间（CI）为 1.14 至 1.58。32 项研究报告了 8129 名参与者的活产率。活产率的 OR 的效应估计值为 1.30，95%CI 为 1.06 至 1.60。21 项研究报告了 5736 名参与者的多胎妊娠率。多胎妊娠率的 OR 的效应估计值为 1.35，95%CI 为 1.07 至 1.71。