Tímár József, Kásler Miklós, Heringh Alexandra, Soós Miklós, Mathiász Dóra, Romány Anna, Józsa Adrienn, Szilák László, Forrai Tamás, Patthy László, Kovács Gábor
Országos Onkológiai Intézet Budapest Semmelweis Egyetem II. sz. Patológiai Intézet 1091 Budapest Ulloi út 93.
Magy Onkol. 2009 Dec;53(4):321-34. doi: 10.1556/MOnkol.53.2009.4.1.
In the 3rd year of the program 8 new molecular diagnostic services have been introduced to clinic in the management of breast-, lung-, colorectal cancers as well as in GIST and melanoma. Two patents have been filed for innovative modulation of mito/motogenic signaling pathways in cancer cells. In preclinical models of human cancer a functional imaging technique was developed to detect vascular eff ects of erythropoietin. Using a genomic approach, the sequential changes in human melanoma during systemic dissemination were determined revealing several novel potential prognostic factors and some interesting novel targets for therapy.
在该项目的第三年，8种新的分子诊断服务已引入临床，用于乳腺癌、肺癌、结直肠癌以及胃肠道间质瘤和黑色素瘤的管理。已就癌细胞中线粒体/促有丝分裂信号通路的创新调节提交了两项专利申请。在人类癌症的临床前模型中，开发了一种功能成像技术来检测促红细胞生成素的血管效应。采用基因组学方法，确定了人类黑色素瘤在全身播散过程中的序贯变化，揭示了几个新的潜在预后因素和一些有趣的新治疗靶点。
