Menkis A H, Novick R J, Kostuk W J, Pflugfelder P W, Powell A M, Thomson D, McKenzie F N
University of Western Ontario, London, Canada.
J Heart Lung Transplant. 1991 Jan-Feb;10(1 Pt 1):28-32.
Chronic shortage of donor organs has heightened interest in new strategies for increasing donor availability. Unacceptable hearts for transplant have previously been characterized by donor age greater than 40 years, more than 20% donor/recipient weight mismatch, ischemic time more than 4 hours, and the presence of coronary artery disease. A series of 185 consecutive orthotopic heart transplants were retrospectively examined. A significant number of donor hearts used were unacceptable by one or more of the above criteria. Our current approach is to match donors to recipients using a wide range of criteria. Donors are now accepted from any location in North America. We have accepted donors more than 55 years of age and donors weighing less than 50% of the recipient's body weight. Because of the chronic shortage of donor organs, donor criteria have been effectively liberalized, thereby increasing the donor pool without compromising the overall results of heart transplantation.
供体器官的长期短缺使得人们对增加供体来源的新策略愈发关注。此前，不适合移植的心脏具有以下特征：供体年龄大于40岁、供体/受体体重不匹配超过20%、缺血时间超过4小时以及存在冠状动脉疾病。对连续进行的185例原位心脏移植手术进行了回顾性研究。大量使用的供体心脏不符合上述一项或多项标准。我们目前的方法是使用多种标准来匹配供体和受体。现在接受来自北美任何地区的供体。我们已经接受了年龄超过55岁以及体重低于受体体重50%的供体。由于供体器官长期短缺，供体标准已有效放宽，从而在不影响心脏移植总体结果的情况下增加了供体库。
