Ladizesky M, Diáz M C, Zeni S, Romeo H E, Cardinali D P, Mautalen C A
Laboratorio de Osteopatías Médicas, Hospital de Clínicas, Buenos Aires, Argentina.
Calcif Tissue Int. 1991 Jan;48(1):63-7. doi: 10.1007/BF02555797.
The functional and anatomic compensatory response of the parathyroid gland was examined in hemiparathyroidectomized (HPTx) rats whose parathyroid hormone (PTH) secretion was stimulated by a low calcium diet. These responses were compared with those observed in the thyroid gland of hemithyroidectomized (HTx) rats. Rats kept on a low calcium diet for 10 days were subjected to HPTx, HTx, or sham operations. Throughout the experiment (up to 28 days after surgery), serum calcium levels of HPTx rats were lower than the basal, with delta values (mg/dl, mean +/- SEM) of -0.66 +/- 0.17 and -0.84 +/- 0.17, (P less than 0.05) 3 and 28 days after surgery, respectively. Serum PTH decreased significantly from 7 to 21 days after HPTx, reaching normality at day 28 after surgery. In HTx rats, serum thyroxine (T4) levels diminished significantly 7 days after surgery, and attained normality thereafter. The mitotic index (number of metaphases/1,000 cells) in parathyroid glands of colchicine-treated HPTx rats increased significantly in comparison to sham-operated controls, when examined 2 or 40 days after surgery. The mitotic index of thyroid follicular cells was significantly higher than that of their respective controls, 2 but not 40 days after HTx. These results indicate that after HPTx, a delayed compensatory response is found when the animals are kept under a low calcium diet. Parathyroid response is both delayed and of a minor degree compared to that found in the thyroid gland after HTx.
在通过低钙饮食刺激甲状旁腺激素（PTH）分泌的半甲状旁腺切除（HPTx）大鼠中，研究甲状旁腺的功能和解剖学代偿反应。将这些反应与半甲状腺切除（HTx）大鼠甲状腺中观察到的反应进行比较。对持续低钙饮食10天的大鼠进行HPTx、HTx或假手术。在整个实验过程中（直至手术后28天），HPTx大鼠的血清钙水平低于基础水平，手术后3天和28天的差值（mg/dl，平均值±标准误）分别为-0.66±0.17和-0.84±0.17，（P<0.05）。HPTx后7至21天血清PTH显著下降，术后28天恢复正常。在HTx大鼠中，血清甲状腺素（T4）水平在手术后7天显著降低，此后恢复正常。与假手术对照组相比，在秋水仙碱处理的HPTx大鼠甲状旁腺中，术后2天或40天检查时，有丝分裂指数（中期细胞数/1000个细胞）显著增加。HTx后2天而非40天，甲状腺滤泡细胞的有丝分裂指数显著高于各自的对照组。这些结果表明，HPTx后，当动物处于低钙饮食时会出现延迟的代偿反应。与HTx后甲状腺中的反应相比，甲状旁腺的反应既延迟且程度较小。
