Centre du Cancer, Department of Medical Oncology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium.
J Oncol. 2010;2010:372547. doi: 10.1155/2010/372547. Epub 2009 Dec 23.
Ovarian cancer is the fifth largest cancer killer in women. Improved understanding of the molecular pathways implicated in the pathogenesis of ovarian cancer has led to the investigation of novel targeted therapies. Ovarian cancer is characterized by an imbalance between pro- and antiangiogenic factors in favor of angiogenesis activation. Various antivascular strategies are currently under investigation in ovarian cancer. They can schematically be divided into antiangiogenic and vascular-disrupting therapies. This paper provides a comprehensive review of these new treatments targeting the tumor vasculature in this disease. Promising activities have been detected in phase II trials, and results of phase III clinical trials are awaited eagerly.
卵巢癌是女性癌症死亡的第五大原因。对卵巢癌发病机制中涉及的分子途径的深入了解,导致了新型靶向治疗的研究。卵巢癌的特征是促血管生成和抗血管生成因子之间的失衡有利于血管生成激活。目前正在对各种抗血管生成策略进行研究,它们可以概括地分为抗血管生成和血管破坏治疗。本文全面综述了这些针对该疾病肿瘤血管的新治疗方法。在 II 期临床试验中已经检测到了有前途的活性,目前正在急切等待 III 期临床试验的结果。