荟萃分析：当研究结果存在差异时得出结论。
Meta-analysis: drawing conclusions when study results vary.
作者信息
Rosenthal Leslie, Schisterman Enrique
机构信息
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA.
出版信息
Methods Mol Biol. 2010;594:427-34. doi: 10.1007/978-1-60761-411-1_30.
Abstract
Low-dose aspirin has been suggested to positively impact a number of clinical outcomes associated with oxidative stress; however, results of clinical trials surrounding its effect on a woman's ability to achieve and sustain pregnancy have been inconclusive. A meta-analysis is an advantageous tool in this situation. Meta-analyses allow researchers to formally and systematically pool together all relevant research in order to clarify findings and form conclusions based on all currently available information. The purpose of this chapter is to describe how to perform a meta-analysis, clarify the impact of model selection, and provide examples of implementation.
摘要
低剂量阿司匹林已被认为对许多与氧化应激相关的临床结果有积极影响；然而，关于其对女性受孕和维持妊娠能力影响的临床试验结果尚无定论。在这种情况下，荟萃分析是一种有利的工具。荟萃分析使研究人员能够正式且系统地汇总所有相关研究，以便根据所有现有信息阐明研究结果并得出结论。本章的目的是描述如何进行荟萃分析，阐明模型选择的影响，并提供实施示例。
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