Kararizou Evangelia, Manta Panagiota, Kalfakis Nikolaos, Vassilopoulos Demetrios
Neurologic Clinic, Aeginition Hospital, 72-74, Vass. Sofias Ave. 11528, Athens, Greece.
Pol J Pathol. 2009;60(4):186-8.
The purpose of the present study is to investigate the age-related changes in muscle biopsies from the quadriceps femoris in male subjects of different ages.
A histological and histochemical study was performed on specimens from the quadriceps femoris from 8 males divided into two groups, under 50 and over 70 years of age. The following measurements were performed: a) number of type 1 and 2 fibres, b) diameter of type 1 and 2 fibres, c) percentage of the number and mean diameter of the two types in the interior and the peripheral area of fascicles.
The proportion of type 2 fibres decreased significantly with age (p < 0.005), especially in the periphery of the fascicles, but the proportion of type 1 fibres was not significantly changed. The correlation of fibre size with age showed that type 2 fibres decrease in size with age. This finding was more evident in the periphery of the fascicles (p < 0.05).
We found that type 2 skeletal muscle fibres decreased in size and proportion with increasing age. The existence of these age changes should be taken into account in the interpretation of muscle biopsies of aged individuals.
本研究旨在调查不同年龄男性受试者股四头肌肌肉活检中与年龄相关的变化。
对8名男性的股四头肌标本进行了组织学和组织化学研究，这些男性被分为两组，年龄在50岁以下和70岁以上。进行了以下测量：a）1型和2型纤维的数量，b）1型和2型纤维的直径，c）束内部和周边区域中两种类型纤维的数量百分比和平均直径。
2型纤维的比例随年龄显著降低（p < 0.005），尤其是在束的周边，但1型纤维的比例没有显著变化。纤维大小与年龄的相关性表明，2型纤维的大小随年龄减小。这一发现在束的周边更为明显（p < 0.05）。
我们发现，随着年龄的增长，2型骨骼肌纤维的大小和比例降低。在解释老年个体的肌肉活检结果时，应考虑到这些年龄变化的存在。
