血管侵犯对Ⅰ期手术治疗的非小细胞肺癌患者预后的影响。

The effect of blood vessel invasion on prognosis of operated stage I non-small cell lung cancer patients.

作者信息

Turhan K, Samancilar O, Cagirici U, Goksel T, Nart D, Cakan A, Cok G

机构信息

Department of Thoracic Surgery, Ege University Medical Faculty, Izmir, Turkey.

出版信息

Thorac Cardiovasc Surg. 2010 Feb;58(1):28-31. doi: 10.1055/s-0029-1185881. Epub 2010 Jan 13.

DOI:10.1055/s-0029-1185881

PMID:20072973

Abstract

OBJECTIVE

A retrospective study was conducted to identify the effect of blood vessel invasion on prognosis in surgically treated stage I non-small cell lung cancer patients.

METHODS

A total of 71 consecutive patients who had undergone complete resection for stage I primary non-small cell lung cancer (NSCLC) between 1998 and 2007 were evaluated. All pathological specimens were examined for evidence of blood vessel invasion. The follow-up period was 5-118 months. Survival data were analyzed for all patients using the Kaplan-Meier test.

RESULTS

There were 63 men and 8 women (mean age 59.2, age range 35-86). The most common tumor types were adenocarcinoma (35 patients, 49 %) and squamous cell carcinoma (26 patients, 37 %). Twenty-five patients (35 %) had stage IA disease, and 46 had (65 %) stage IB disease. In 13 cases (18 %) blood vessel invasion was demonstrated, whereas in the remaining 58 cases there was no evidence of vascular invasion. Minimum and maximum follow-up periods were 5 and 118 months respectively, with a mean of 41.76 +/- 27 months (median 33.5 months). Overall disease-free survival was 79.6 +/- 6.4 months: 38.3 +/- 12.0 months for the group with blood vessel invasion and 87.5 +/- 6.7 months for the remaining group. The difference between the two groups was statistically significant ( P < 0.003). Overall survival rate was 86.7 +/- 6.7 months: 44.5 +/- 11.3 months for blood vessel invasion group and 98.2 +/- 6.2 months for the remaining group. The difference between the two groups was statistically significant ( P < 0.001).

CONCLUSION

Vascular invasion can be an important factor for predicting unfavorable prognosis in stage I NSCLC patients.

摘要

目的

进行一项回顾性研究，以确定血管侵犯对手术治疗的Ⅰ期非小细胞肺癌患者预后的影响。

方法

对1998年至2007年间连续71例接受Ⅰ期原发性非小细胞肺癌（NSCLC）根治性切除术的患者进行评估。所有病理标本均检查有无血管侵犯证据。随访期为5至118个月。使用Kaplan-Meier检验对所有患者的生存数据进行分析。

结果

男性63例，女性8例（平均年龄59.2岁，年龄范围35至86岁）。最常见的肿瘤类型为腺癌（35例，49%）和鳞状细胞癌（26例，37%）。25例（35%）为ⅠA期疾病，46例（65%）为ⅠB期疾病。13例（18%）显示有血管侵犯，而其余58例无血管侵犯证据。最短和最长随访期分别为5个月和118个月，平均为41.76±27个月（中位数33.5个月）。总体无病生存期为79.6±6.4个月：血管侵犯组为38.3±12.0个月，其余组为87.5±6.7个月。两组之间差异有统计学意义（P<0.003）。总生存率为86.7±6.7个月：血管侵犯组为44.5±11.3个月，其余组为98.2±6.2个月。两组之间差异有统计学意义（P<0.001）。