Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, China.
IUBMB Life. 2010 Feb;62(2):132-9. doi: 10.1002/iub.298.
Phenotypic switching and proliferation of vascular smooth muscle cells (VSMCs) are critical components in the development of many vascular proliferation diseases such as atherosclerosis and restenosis after percutaneous coronary interventions. Krüppel-like factor 4 (KLF4) has been shown to play a key role in VSMC proliferation and differentiation. The focus of this review is to provide an overview for understanding the physiological and pathobiological roles of KLF4 in phenotypic switching and proliferation of VSMCs.
血管平滑肌细胞（VSMCs）的表型转换和增殖是许多血管增殖性疾病（如动脉粥样硬化和经皮冠状动脉介入治疗后的再狭窄）发展的关键组成部分。Krüppel 样因子 4（KLF4）已被证明在 VSMC 增殖和分化中发挥关键作用。本综述的重点是提供对 KLF4 在 VSMCs 表型转换和增殖中的生理和病理生物学作用的理解概述。
