Xin Suyalatu, Liu Wenzhong, Cheng Biao
Department of Orthopedics, Center Hospital of Erdos, Erdos Inner Mongolia, 017000, P.R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Dec;23(12):1502-5.
To review the regulating effects of estrogen on endothelial cell functions, the involved endothelial progenitor cells (EPCs), and the related VEGF, and explore the mechanism of estrogen participating in new vessel formation on wound basement and wound healing.
Recent literature about biological effects of estrogen on capillary vessel formation was reviewed.
The formation of new vessel in the wound's granulation tissue contained vasculogenesis and vascularization, and the new vessels could transport the oxygen and nutrient for the metabolism of the local healing tissue. The estrogen effected vascular endothelial cells through its receptors. Peripheral vascular EPCs differentiated into endothelial cells and participated into the formation of new vessels. Estradiol exerted influences on the dynamics of vascular EPCs and the neovascularization. VEGF was a key mediator in the processes of estradiol regulating angiogenesis.
Understanding the molecular mechanisms that regulate vessel formation in wound healing, especially how estrogen modulates its receptor and angiogenic factor, may provide new approaches for managing wound healing.
综述雌激素对内皮细胞功能、相关内皮祖细胞（EPCs）及血管内皮生长因子（VEGF）的调节作用，探讨雌激素参与伤口基底血管新生及伤口愈合的机制。
回顾近期有关雌激素对毛细血管形成生物学效应的文献。
伤口肉芽组织中新生血管的形成包括血管发生和血管形成，新生血管可为局部愈合组织的代谢输送氧气和营养物质。雌激素通过其受体作用于血管内皮细胞。外周血EPCs分化为内皮细胞并参与新生血管的形成。雌二醇对血管EPCs的动态变化及新生血管形成有影响。VEGF是雌二醇调节血管生成过程中的关键介质。
了解伤口愈合过程中调节血管形成的分子机制，尤其是雌激素如何调节其受体和血管生成因子，可能为伤口愈合的处理提供新方法。
