Department of Pathology, University of Ulsan College of Medicine, Seoul, Korea.
Cancer Invest. 2010 Jun;28(5):505-14. doi: 10.3109/07357900902783179.
Epidermal growth factor (EGF) stimulates apoptosis in tumor cells depending on the expression levels of EGF receptor and Her2. We examined the protein levels in 22 different cancer cell lines and assessed the responses to EGF. EGF-induced cytotoxicity was not correlated with the levels of either EGFR or Her2. Fourteen cell lines exhibited decreased cell proliferation, whereas 293T cells did not display any noticeable changes and degraded transiently expressed EGFR following EGF treatment. EGF treatment resulted in significant tumor growth inhibition in some xenografts. Our data indicate that exogenous EGF treatment leads to growth inhibition rather than inducing tumor cell proliferation.
表皮生长因子（EGF）通过 EGF 受体和 Her2 的表达水平来刺激肿瘤细胞凋亡。我们检测了 22 种不同的癌细胞系中的蛋白水平，并评估了它们对 EGF 的反应。EGF 诱导的细胞毒性与 EGFR 或 Her2 的水平无关。14 种细胞系表现出细胞增殖减少，而 293T 细胞在 EGF 处理后没有显示出任何明显的变化，并且短暂表达的 EGFR 降解。EGF 处理导致一些异种移植肿瘤的生长明显受到抑制。我们的数据表明，外源性 EGF 处理导致生长抑制而不是诱导肿瘤细胞增殖。
