Schanzenbächer P, Grimme M, Walter U, Kochsiek K
Medizinische Klinik, Universität Würzburg.
Dtsch Med Wochenschr. 1991 Mar 29;116(13):481-5. doi: 10.1055/s-2008-1063636.
A comparison was made in 79 patients (63 men, 16 women: mean age 52 +/- 9 years) of the effect of high and low doses of aspirin on restenosis rate during the first six months after originally successful percutaneous transluminal coronary angioplasty (PTCA), 39 patients (group 1) received 1000 mg aspirin daily, while 40 (group 2) received 100 mg daily. All patients took 1000 mg aspirin as loading dose on the day before PTCA, and additionally calcium antagonists and slow-release nitrates in the post-PTCA period. Both groups were comparable with respect of localization of the dilated coronary artery stenosis and the morphological changes after dilatation. Intimal lesions after PTCA were demonstrated in 9 patients of group 1 and 10 of group 2. Within six months clinically significant restenosis had occurred in 8 patients of group 1 and 7 of group 2. 33 patients in group 2 and 31 in group 1 were free of symptoms and had no ischaemic reaction on the exercise ECG six months after the initial successful PTCA. These results demonstrate that high aspirin dosage does not reduce the restenosis rate more than low dosage.
对79例患者（63例男性，16例女性：平均年龄52±9岁）进行了比较，观察高剂量和低剂量阿司匹林对最初成功的经皮腔内冠状动脉成形术（PTCA）后前六个月再狭窄率的影响。39例患者（第1组）每日服用1000毫克阿司匹林，而40例（第2组）每日服用100毫克。所有患者在PTCA前一天服用1000毫克阿司匹林作为负荷剂量，并且在PTCA后期间额外服用钙拮抗剂和缓释硝酸盐。两组在扩张冠状动脉狭窄的部位和扩张后的形态学变化方面具有可比性。第1组9例患者和第2组10例患者在PTCA后出现内膜病变。在六个月内，第1组8例患者和第2组7例患者发生了具有临床意义的再狭窄。在最初成功的PTCA六个月后，第2组33例患者和第1组31例患者无症状，运动心电图上无缺血反应。这些结果表明，高剂量阿司匹林并不比低剂量更能降低再狭窄率。
