Institute of Experimental Internal Medicine, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Biochem Soc Trans. 2010 Feb;38(Pt 1):156-61. doi: 10.1042/BST0380156.
The transcription factor NF-kappaB (nuclear factor kappaB) exerts crucial functions in the regulation of innate and adaptive immune responses, wound healing and tissue maintenance and in the development of immune cells. Tight control of NF-kappaB is essential for an efficient defence against pathogens and environmental stress to protect organisms from inflammatory diseases including cancer. An involvement of the CSN (COP9 signalosome) in the regulation of NF-kappaB has been discovered recently. The CSN is a conserved multiprotein complex, which mainly functions in the control of proteolysis. Here, we review recent observations indicating important roles of the CSN in the control of NF-kappaB in innate immunity, as well as T-cell activation and maturation.
转录因子 NF-κB（核因子 kappaB）在调节先天和适应性免疫反应、伤口愈合和组织维持以及免疫细胞发育方面发挥着至关重要的作用。NF-κB 的严格控制对于有效抵御病原体和环境压力以保护生物体免受包括癌症在内的炎症性疾病至关重要。最近发现 COP9 信号osome（CSN）参与了 NF-κB 的调节。CSN 是一种保守的多蛋白复合物，主要功能是控制蛋白水解。在这里，我们回顾了最近的观察结果，这些结果表明 CSN 在先天免疫、T 细胞激活和成熟过程中对 NF-κB 的控制中发挥着重要作用。
