Siebenlist Ulrich, Brown Keith, Claudio Estefania
Immune Activation Section, Laboratory of Immune Regulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1876, USA.
Nat Rev Immunol. 2005 Jun;5(6):435-45. doi: 10.1038/nri1629.
The evolutionarily conserved nuclear factor-kappaB family of transcription factors is known to have a crucial role in rapid responses to stress and pathogens, inducing transcription of many genes that are essential for host defence. Now, studies of mice that are deficient in nuclear factor-kappaB-family members (or deficient in the activation of these factors) reveal that nuclear factor-kappaB is extensively involved in the development of T cells and B cells. And, as we review here, although these factors have several roles, their primary cell-autonomous function is to ensure lymphocyte survival at various developmental stages. This function is subverted in numerous diseases and can lead, for example, to survival of self-reactive lymphocytes or tumour cells.
众所周知，进化上保守的核因子-κB转录因子家族在对应激和病原体的快速反应中起关键作用，可诱导许多宿主防御所必需的基因转录。现在，对核因子-κB家族成员缺陷（或这些因子激活缺陷）小鼠的研究表明，核因子-κB广泛参与T细胞和B细胞的发育。而且，正如我们在此所综述的，尽管这些因子有多种作用，但其主要的细胞自主功能是确保淋巴细胞在各个发育阶段的存活。该功能在许多疾病中被破坏，例如可导致自身反应性淋巴细胞或肿瘤细胞的存活。
