Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Biochem Soc Trans. 2010 Feb;38(Pt 1):223-8. doi: 10.1042/BST0380223.
The p53 family of transcription factors is made up of p53, p63 and p73, which share significant structural homology. In particular, transcriptional complexity and the expression of multiple protein isoforms are an emergent trait of all family members. p63 is the evolutionarily eldest member of the p53 family and the various isoforms have critical roles in the development of stratifying epithelia. Recent results have uncovered additional splice variants, adding to the complexity of the transcriptional architecture of p63. These observations and the emerging extensive interplay between p63 and p53 in development, proliferation and differentiation underline the importance of considering all isoforms and family members in studies of the function of p53 family members.
p53 转录因子家族由 p53、p63 和 p73 组成，它们具有显著的结构同源性。特别是，转录复杂性和多种蛋白质同工型的表达是所有家族成员的新兴特征。p63 是 p53 家族中进化最古老的成员，其各种同工型在分层上皮的发育中起着关键作用。最近的研究结果揭示了额外的剪接变体，增加了 p63 转录结构的复杂性。这些观察结果以及 p63 和 p53 在发育、增殖和分化过程中的新兴广泛相互作用，突显了在研究 p53 家族成员的功能时考虑所有同工型和家族成员的重要性。
