p63 和 p73，p53 的祖先。
p63 and p73, the ancestors of p53.
机构信息
Institute of Biophysical Chemistry, Goethe University, Frankfurt am Main, Germany.
出版信息
Cold Spring Harb Perspect Biol. 2010 Sep;2(9):a004887. doi: 10.1101/cshperspect.a004887. Epub 2010 May 19.
Abstract
p73 and p63 are two homologs of the tumor suppressive transcription factor p53. Given the high degree of structural similarity shared by the p53 family members, p73 and p63 can bind and activate transcription from the majority of the p53-responsive promoters. Besides overlapping functions shared with p53 (i.e., induction of apoptosis in response to cellular stress), the existence of extensive structural variability within the family determines unique roles for p63 and p73. Their crucial and specific functions in controlling development and differentiation are well exemplified by the p63 and p73 knockout mouse phenotypes. Here, we describe the contribution of p63 and p73 to human pathology with emphasis on their roles in tumorigenesis and development.
摘要
p73 和 p63 是肿瘤抑制转录因子 p53 的两个同源物。鉴于 p53 家族成员之间具有高度的结构相似性，p73 和 p63 可以结合并激活大多数 p53 反应启动子的转录。除了与 p53 共享的重叠功能（即响应细胞应激诱导细胞凋亡）外，家族内广泛的结构可变性决定了 p63 和 p73 的独特作用。p63 和 p73 敲除小鼠表型很好地说明了它们在控制发育和分化方面的关键和特定作用。在这里，我们描述了 p63 和 p73 对人类病理学的贡献，重点介绍了它们在肿瘤发生和发展中的作用。
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