mRNA 输出衔接子的结构与功能。
Structure and function of mRNA export adaptors.
机构信息
Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK.
出版信息
Biochem Soc Trans. 2010 Feb;38(Pt 1):232-6. doi: 10.1042/BST0380232.
The mRNA export adaptors provide an important link between multiple nuclear mRNA processing events and the mRNA export receptor TAP/NXF1/Mex67p. They are recruited to mRNA through transcriptional and post-transcriptional events, integrating this information to licence mRNA for export. Subsequently they hand mRNA over to TAP and switch TAP to a higher-affinity RNA-binding state, ensuring its stable association with mRNA destined for export. Here we discuss the structure and function of adaptors and how they are recruited to mRNA.
mRNA 输出衔接因子为多个核 mRNA 加工事件与 mRNA 输出受体 Tap/NXF1/Mex67p 之间提供了重要的联系。它们通过转录和转录后事件被募集到 mRNA 上，整合这些信息以允许 mRNA 进行输出。随后，它们将 mRNA 交给 Tap，并将 Tap 切换到更高亲和力的 RNA 结合状态，确保其与即将输出的 mRNA 稳定结合。在这里，我们讨论衔接因子的结构和功能，以及它们如何被募集到 mRNA 上。
Zotero 插件