School of Biological and Biomedical Sciences, Durham University, South Road, Durham DH1 3LE, UK.
Biochem Soc Trans. 2010 Feb;38(Pt 1):297-300. doi: 10.1042/BST0380297.
Lamins are multifunctional proteins that are often aberrantly expressed or localized in tumours. Here, we endeavour to assess their uses as cancer biomarkers: to diagnose tumours, analyse cancer characteristics and predict patient survival. It appears that the nature of lamin function in cancer is very complex. Lamin expression can be variable between and even within cancer subtypes, which limits their uses as diagnostic biomarkers. Expression of A-type lamins is a marker of differentiated tumour cells and has been shown to be a marker of good or poor patient survival depending on tumour subtype. Further research into the functions of lamins in cancer cells and the mechanisms that determine its patterns of expression may provide more potential uses of lamins as cancer biomarkers.
核纤层蛋白是多功能蛋白，在肿瘤中常出现异常表达或定位。在此，我们致力于评估其作为癌症生物标志物的用途：诊断肿瘤、分析癌症特征和预测患者生存。核纤层蛋白在癌症中的功能性质似乎非常复杂。核纤层蛋白的表达在肿瘤亚型之间甚至在同一肿瘤亚型内都可能存在差异，这限制了它们作为诊断生物标志物的用途。A 型核纤层蛋白的表达是分化肿瘤细胞的标志物，其作为标志物对患者生存的影响取决于肿瘤亚型，或好或差。进一步研究核纤层蛋白在癌细胞中的功能及其决定其表达模式的机制，可能为核纤层蛋白作为癌症生物标志物提供更多的潜在用途。
