Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.
J Integr Plant Biol. 2010 Jan;52(1):8-16. doi: 10.1111/j.1744-7909.2010.00904.x.
Cell division and differentiation of stem cells are controlled by non-cell-autonomous signals in higher organisms. The plant vascular meristem is a stem-cell tissue comprising procambial cells that produce xylem cells on one side and phloem cells on the other side. Recent studies have revealed that TDIF (tracheary element differentiation inhibitory factor)/CLE41/CLE44 peptide signal controls the procambial cell fate in a non-cell-autonomous manner. TDIF produced in and secreted from phloem cells is perceived by TDR/PXY, a leucine-rich repeat receptor kinase located in the plasma membrane of procambial cells. This signal suppresses xylem cell differentiation of procambial cells and promotes their proliferation. In addition to TDIF, some other CLE peptides play roles in vascular development. Here, we summarize recent advances in CLE signaling governing vascular development.
干细胞的细胞分裂和分化受高等生物中非细胞自主信号的控制。植物维管束分生组织是一种干细胞组织，包括原形成层细胞，它们在一侧产生木质部细胞，在另一侧产生韧皮部细胞。最近的研究表明，TDIF（导管分化抑制因子）/CLE41/CLE44 肽信号以非细胞自主的方式控制原形成层细胞的命运。在韧皮部细胞中产生并分泌的 TDIF 被位于原形成层细胞质膜上的 TDR/PXY（富含亮氨酸重复受体激酶）感知。该信号抑制原形成层细胞的木质部细胞分化，并促进其增殖。除了 TDIF 之外，一些其他的 CLE 肽在血管发育中发挥作用。在这里，我们总结了 CLE 信号在血管发育中的最新进展。
