Institute for Immunology, Ludwig-Maximilians-University, Munich, Germany.
FEBS Lett. 2010 Apr 2;584(7):1405-10. doi: 10.1016/j.febslet.2010.01.008. Epub 2010 Jan 12.
Macroautophagy, a homeostatic process that shuttles cytoplasmic constituents into endosomal and lysosomal compartments, has recently been shown to deliver antigens for presentation on major histocompatibility complex (MHC) class II. Autophagy-mediated antigen processing in thymic epithelial cells has been suggested to be involved in the generation of a self-MHC restricted and self-tolerant CD4(+) T cell repertoire. Furthermore, there is accumulating evidence that the up-regulation of autophagy by pattern-recognition receptor signaling represents an innate defense mechanism against intracellular pathogens. Thus, through linking pathogen breakdown with the presentation of pathogen-derived autophagy substrates on MHC class II, autophagy serves a dual function at the interface of the innate and the adaptive immune response.
自噬是一种将细胞质成分输送到内体和溶酶体隔室的稳态过程，最近已被证明可以将抗原递呈给主要组织相容性复合体 (MHC) Ⅱ类。自噬介导的胸腺上皮细胞中的抗原加工被认为参与了自身 MHC 限制和自身耐受 CD4(+)T 细胞库的产生。此外，越来越多的证据表明，模式识别受体信号对自噬的上调代表了一种针对细胞内病原体的先天防御机制。因此，通过将病原体的分解与 MHC Ⅱ类上的自噬底物的呈递联系起来，自噬在先天免疫和适应性免疫反应的界面上发挥双重功能。
