Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR), Gijubhai Badheka Marg, Bhavnagar 364 002, Gujarat, India.
Int J Pharm. 2010 Mar 30;388(1-2):280-6. doi: 10.1016/j.ijpharm.2010.01.002. Epub 2010 Jan 13.
The study deals with the intercalation of procainamide hydrochloride (PA), an antiarrythmia drug in montmorillonite (MMT), as a new drug delivery device. Optimum intercalation of PA molecules within the interlayer space of MMT was achieved by means of different reaction conditions. Intercalation of PA in the MMT galleries was conformed by X-ray diffraction (XRD), Fourier transform infrared spectra (FT-IR), and thermal analysis (DSC). In order to retard the quantity of drug release in the gastric environment, the prepared PA-MMT composite was compounded with alginate (AL), and further coated with chitosan (CS). The surface morphology of the PA-MMT-AL and PA-MMT-AL-CS nanocomposites beads was analyzed by scanning electron microscope (SEM). The in vitro release experiments revealed that AL and CS were able to retard the drug release in gastric environments, and release the drug in the intestinal environments with a controlled manner. The release profiles of PA from composites were best fitted in Higuchi kinetic model, and Korsmeyer-Peppas model suggested diffusion controlled release mechanism.
该研究涉及普鲁卡因胺盐酸盐（PA）在蒙脱石（MMT）中的插层，作为一种新的药物传递装置。通过不同的反应条件，实现了 PA 分子在 MMT 层间空间中的最佳插层。PA 在 MMT 层间的插层通过 X 射线衍射（XRD）、傅里叶变换红外光谱（FT-IR）和热分析（DSC）得到证实。为了延缓胃环境中药物的释放量，制备的 PA-MMT 复合材料与藻酸盐（AL）复合，并进一步用壳聚糖（CS）进行涂层。通过扫描电子显微镜（SEM）分析了 PA-MMT-AL 和 PA-MMT-AL-CS 纳米复合材料珠的表面形态。体外释放实验表明，AL 和 CS 能够延缓胃环境中的药物释放，并以可控的方式在肠道环境中释放药物。PA 从复合材料中的释放曲线最符合 Higuchi 动力学模型，Korsmeyer-Peppas 模型表明扩散控制释放机制。
