多巴胺和腺苷酸环化酶磷酸蛋白32（DARPP-32）与tra2-β1结合并影响可变剪接。
DARPP-32 binds to tra2-beta1 and influences alternative splicing.
作者信息
Benderska Natalya, Becker Kristina, Girault Jean-Antoine, Becker Cord-Michael, Andreadis Athena, Stamm Stefan
机构信息
University of Erlangen-Nuremberg, Institute for Biochemistry, Fahrstrasse 17, 91054 Erlangen, Germany.
出版信息
Biochim Biophys Acta. 2010 May-Jun;1799(5-6):448-53. doi: 10.1016/j.bbagrm.2010.01.003. Epub 2010 Jan 13.
Abstract
The majority of human genes undergo alternative splicing, which is frequently altered in response to physiological stimuli. DARPP-32 (dopamine and cAMP regulated phosphoprotein, 32kDa) is a component of PKA-dependent signaling pathways. Here we show that DARPP-32 binds directly to the splicing factor tra2-beta1 (transformer 2). DARPP-32 changes the usage of tra2-beta1 dependent alternative exons in a concentration-dependent manner, suggesting that the DARPP-32:tra2-beta1 interaction is a molecular link between signaling pathways and pre-mRNA processing.
摘要
大多数人类基因会经历可变剪接，这种剪接通常会因生理刺激而发生改变。DARPP-32（多巴胺和cAMP调节磷蛋白，32 kDa）是PKA依赖性信号通路的一个组成部分。在此我们表明，DARPP-32直接与剪接因子tra2-β1（转化蛋白2）结合。DARPP-32以浓度依赖的方式改变tra2-β1依赖性可变外显子的使用情况，这表明DARPP-32与tra2-β1的相互作用是信号通路与前体mRNA加工之间的分子联系。
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