马达加斯加雨林中的青牛胆三萜。
Euphane triterpenoids of Cassipourea lanceolata from the Madagascar rainforest.
机构信息
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA.
出版信息
Phytochemistry. 2010 Apr;71(5-6):669-74. doi: 10.1016/j.phytochem.2009.12.009. Epub 2010 Jan 13.
Abstract
Fractionation of an ethanol extract of a Madagascar collection of the leaves and fruit of Cassipourea lanceolata Tul. led to the isolation of three euphane triterpenoids 1-3. The (1)H and (13)C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, TOCSY, HSQC (HMQC), HMBC and ROESY sequences. The three compounds showed weak antiproliferative activities against the A2780 human ovarian cancer cell line, with IC(50) values of 25, 25 and 32 microM, respectively.
摘要
从马达加斯加收集的叶和果的 Cassipourea lanceolata Tul. 的乙醇提取物中进行分段，分离得到三种 euphane 三萜 1-3。使用二维 NMR 实验（包括 COSY、TOCSY、HSQC（HMQC）、HMBC 和 ROESY 序列）的组合，对所有化合物的 (1)H 和 (13)C NMR 谱进行了完全归属。这三种化合物对 A2780 人卵巢癌细胞系表现出较弱的抗增殖活性，IC(50)值分别为 25、25 和 32 microM。
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