从 Malosana 山桂花树皮中分离得到的成分的结构及其对人卵巢癌细胞系的细胞毒性。

Structure of constituents isolated from the bark of Cassipourea malosana and their cytotoxicity against a human ovarian cell line.

机构信息

Medicinal Cell Biology, Kobe Pharmaceutical University, Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Hyogo, Japan.

Hyogo Cancer Center, Kitaoji-chou, Akashi, 673-8558, Hyogo, Japan.

出版信息

J Nat Med. 2019 Jan;73(1):289-296. doi: 10.1007/s11418-018-1254-2. Epub 2018 Oct 23.

DOI:10.1007/s11418-018-1254-2

PMID:30353358

Abstract

Three aromatic compounds, 2α,3α-epoxyflavan-5,7,4'-triol-(4β → 8)-afzelechin (1), 2β,3β-epoxyflavan-5,7,4'-triol-(4α → 8)-epiafzelechin (2), and methyl 4-ethoxy-2-hydroxy-6-propylbenzoate (3), as well as eight known compounds (4-11) were isolated from the bark of Cassipourea malosana (Rhizophoraceae). Their structures were determined on the basis of an analysis of spectroscopic data. The in vitro cytotoxic activities of these compounds against human ovarian cancer cell line TOV21G were evaluated. Most compounds showed little activity; however, the methyl derivatives of flavan dimers (1a and 2a) showed higher activity (IC value of 30.3 and 75.4 μM) than parent compounds 1 and 2.

摘要

从Cassipourea malosana（Rhizophoraceae）树皮中分离得到三种芳香族化合物，2α，3α-环氧黄烷-5，7，4'-三醇-（4β→8）-afzelechin（1），2β，3β-环氧黄烷-5，7，4'-三醇-（4α→8）-epiafzelechin（2）和甲基 4-乙氧基-2-羟基-6-丙基苯甲酸酯（3），以及八种已知化合物（4-11）。根据光谱数据分析确定了它们的结构。评估了这些化合物对人卵巢癌细胞系 TOV21G 的体外细胞毒性活性。大多数化合物活性较小；然而，黄烷二聚体的甲基衍生物（1a 和 2a）比母体化合物 1 和 2 显示出更高的活性（IC 值为 30.3 和 75.4μM）。