CpG-ODN 刺激的增殖反应可预测慢性淋巴细胞白血病患者的无进展生存期、总生存期和总反应率。
The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia.
机构信息
Department of Haematology, Catholic University Hospital "A. Gemelli", Largo A. Gemelli, 8, 00168 Rome, Italy.
出版信息
Leuk Res. 2010 Sep;34(9):1189-94. doi: 10.1016/j.leukres.2009.12.020. Epub 2010 Jan 13.
We recently reported that leukemic cells from IgVH-unmutated/progressive CLL more frequently proliferate in response to CpG-ODN stimulation than their corresponding counterparts. Here we evaluated the prognostic impact of this proliferative response in 91 CLL patients. The proliferative response was highly predictive of PFS, TTT and OS in the whole series and refined prognosis in patients with M-CLL. BCR stimulation modulated the response to CpG-ODN, suggesting that the proliferative capacity of the leukemic cells is related to antigen-encounter history. These data support the hypothesis that the capacity of the leukemic cells to respond to external stimuli influences disease progression in CLL.
我们最近报道称，与相应的 IgVH 未突变/进展性 CLL 相比，IgVH 未突变/进展性 CLL 中的白血病细胞对 CpG-ODN 刺激的增殖反应更为频繁。在这里，我们评估了这种增殖反应在 91 例 CLL 患者中的预后影响。在整个系列中，增殖反应高度预测 PFS、TTT 和 OS，并细化了 M-CLL 患者的预后。BCR 刺激调节了对 CpG-ODN 的反应，表明白血病细胞的增殖能力与抗原遭遇史有关。这些数据支持这样一种假设，即白血病细胞对外界刺激的反应能力影响 CLL 的疾病进展。
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