Rohrig Timothy P, Gamble Megan, Cox Kim
Regional Forensic Science Center, Wichita, KS, USA.
Methods Mol Biol. 2010;603:317-26. doi: 10.1007/978-1-60761-459-3_30.
Ketamine hydrochloride, a Schedule III drug under the Controlled Substances Act, is a dissociative anesthetic that has a combination of stimulant, depressant, hallucinogenic, and analgesic properties. This procedure utilizes solid phase extraction of blood, tissue, or urine samples to isolate ketamine (special K) and its metabolite norketamine. The extract is then assayed using selected ion monitoring gas chromatography/mass spectrometry for absolute structural confirmation of the compound and the compounds quantified by comparing responses of the unknown samples to the responses of standards.
盐酸氯胺酮是《管制物质法》规定的III类药物，是一种分离麻醉剂，具有兴奋剂、抑制剂、致幻剂和镇痛剂的综合特性。本程序利用固相萃取血液、组织或尿液样本，以分离氯胺酮（特殊K）及其代谢产物去甲氯胺酮。然后使用选择离子监测气相色谱/质谱法对提取物进行分析，以对化合物进行绝对结构确认，并通过比较未知样品与标准品的响应来对化合物进行定量。
