Güneş M, Günaldi O, Tuğcu B, Tanriverdi O, Güler A K, Cöllüoğlu B
Bakirkoy Research and Training Hospital for Neurology, Neurosurgery and Psychiatry, Istanbul, Turkey.
Minim Invasive Neurosurg. 2009 Oct;52(5-6):238-41. doi: 10.1055/s-0028-1128117. Epub 2010 Jan 14.
Chondrosarcoma is a rare malignant tumor originating from cartilagenous tissue. It tends to localize in the epiphysis of long bones and pelvic bones. Only 7% of the all chondrosarcomas originate in the craniocervical region.
A 25-year-old man was admitted to our hospital with headache and dizziness. Physical examination and neurological examination were normal. Skull radiography revealed a radioopaque lesion in the right parieto-occipital region. Cranial computed tomography and magnetic resonance imaging showed a mass lesion including calcification areas and homogenous contrast enhancement in the right parieto-occipital region. The tumor was removed totally by a microsurgical technique. A classical type chondrosarcoma was confirmed histopathologically. The patient was discharged with no neurological deficit.
Intracranial chondrosarcoma has been first reported by Mott in 1899. Primary intracranial chondrosarcomas, constitute only less than 0.16% of all brain tumors. Most of them are located at the skull base. The choroid plexus, dura mater and brain parenchyma are extremely rarely invaded. Meningiomas, solitary fibrous tumor, chordoma, hemangiopericytoma, metastasis and vascular malformations should be considered as differential diagnoses. Radical surgical removal of the tumor is the preferred management procedure. Chemotherapy and radiotherapy may by added as adjuvant therapy. We present the case of a patient with an intracranial chondrosarcoma, who has treated successfully with surgical removal.
软骨肉瘤是一种起源于软骨组织的罕见恶性肿瘤。它倾向于定位于长骨骨骺和骨盆骨。所有软骨肉瘤中仅有7%起源于颅颈区域。
一名25岁男性因头痛和头晕入院。体格检查和神经检查均正常。颅骨X线摄影显示右侧顶枕部有一不透X线的病变。头颅计算机断层扫描和磁共振成像显示右侧顶枕部有一肿块病变,包括钙化区域和均匀强化。通过显微外科技术将肿瘤完全切除。组织病理学确诊为经典型软骨肉瘤。患者出院时无神经功能缺损。
颅内软骨肉瘤于1899年由莫特首次报道。原发性颅内软骨肉瘤仅占所有脑肿瘤的不到0.16%。它们大多位于颅底。脉络丛、硬脑膜和脑实质极少受侵犯。应考虑将脑膜瘤、孤立性纤维瘤、脊索瘤、血管外皮细胞瘤、转移瘤和血管畸形作为鉴别诊断。肿瘤的根治性手术切除是首选的治疗方法。化疗和放疗可作为辅助治疗。我们报告了一例颅内软骨肉瘤患者,经手术切除成功治疗。