Kentucky Injury Prevention and Research Center, College of Public Health, University of Kentucky, Lexington, KY 40504, USA.
Pharmacoepidemiol Drug Saf. 2010 Feb;19(2):124-31. doi: 10.1002/pds.1901.
The methadone poisoning death rate for Kentucky in the year 2005 was the sixth highest in the US and increased 17-fold from 1999 to 2005. The purpose of this study was to identify and characterize methadone related poisonings in Kentucky using multiple data sources: inpatient hospitalization discharge data, poison control center data, vital statistics mortality data, and Kentucky All Schedule Prescription Electronic Reporting (KASPER) data.
A descriptive analysis study was performed on Kentucky inpatient hospitalization discharge data, Kentucky Regional Poison Center (KRPC) data, Kentucky vital statistics mortality data, and KASPER data.
While methadone prescription rates decreased from a peak of 27 prescriptions per 1000 population in the year 2003 to 21 in 2007, there was a statistically significant increase in inpatient hospitalization rates, and KRPC call rates (years 2001-2007), and in mortality rates (years 2001-2005). The highest methadone related inpatient hospitalization rates and mortality rates were observed in the rural Appalachian region of Kentucky. Inpatient methadone related hospitalizations occurred most frequently among males from 25 to 34 years of age and among females from 35 to 44 years of age. Medicare and Medicaid were billed for over half of the patients over the age of 34 hospitalized for methadone related poisoning. The expected payer source for six of the inpatient hospitalization patients was workers' compensation, mostly due to unintentional methadone poisonings at work.
Utilizing multiple data sources, the results of this study show that unintentional and intentional methadone related poisonings are a continuing and escalating problem in Kentucky, particularly in the Appalachian region.
2005 年肯塔基州的美沙酮中毒死亡率位居全美第六，与 1999 年相比增加了 17 倍。本研究的目的是利用多个数据源（住院患者出院数据、中毒控制中心数据、死亡统计数据和肯塔基州所有处方电子报告系统 (KASPER) 数据）识别和描述肯塔基州的美沙酮中毒情况。
对肯塔基州住院患者出院数据、肯塔基州区域中毒控制中心 (KRPC) 数据、肯塔基州死亡统计数据和 KASPER 数据进行描述性分析研究。
虽然美沙酮处方率从 2003 年的每 1000 人 27 剂的峰值下降到 2007 年的 21 剂，但住院率、KRPC 呼叫率（2001-2007 年）和死亡率（2001-2005 年）均呈统计学显著上升趋势。肯塔基州农村阿巴拉契亚地区观察到最高的美沙酮相关住院率和死亡率。25 至 34 岁的男性和 35 至 44 岁的女性中，与美沙酮相关的住院治疗最常见。医疗保险和医疗补助为超过一半年龄超过 34 岁因美沙酮相关中毒住院的患者付费。在因美沙酮中毒住院的患者中，有 6 人预期的付费方来源是工人赔偿，主要是因为在工作中意外摄入美沙酮。
利用多个数据源，本研究结果表明，肯塔基州尤其是阿巴拉契亚地区，非故意和故意的美沙酮中毒是一个持续且不断加剧的问题。
