Colemont L J, Harrier H D, Shoemaker W C
Department of Internal Medicine, St. Vincentius Hospital, University of Antwerp, Belgium.
J Clin Gastroenterol. 1991 Feb;13(1):91-3. doi: 10.1097/00004836-199102000-00020.
We report a 33-year-old man who developed cutaneous necrosis of the lower extremities with extensive bulla formation after i.v. administration of vasopressin for the treatment of bleeding esophageal varices. Due to its potent nonselective vasoconstrictive action, vasopressin not only may induce cardiac and gastrointestinal ischemia, but cutaneous ischemia as well. As in our patient, this may lead to extensive necrotic skin lesions at sites distant from the infusion.
我们报告一名33岁男性，在静脉注射血管加压素治疗食管静脉曲张出血后，出现下肢皮肤坏死并伴有广泛水疱形成。由于血管加压素具有强大的非选择性血管收缩作用，它不仅可能导致心脏和胃肠道缺血，还会引起皮肤缺血。就像我们的患者一样，这可能会在远离输液部位的地方导致广泛的坏死性皮肤病变。
