[病毒样颗粒技术研究进展]

[Progress in virus-like particles technique studies].

作者信息

Guo Jian-Qiang, Zhang Zhi-Qing

机构信息

State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.

出版信息

Zhongguo Yi Miao He Mian Yi. 2009 Apr;15(2):167-73.

PMID:20077665

Abstract

Virus-like particles (VLPs) structurally mimic the authentic virus whereas contain no viral genome. VLPs technique plays an important role in basic research such as virus assembly and virus morphology diversity. With special immunology properties, VLPs vaccine can induce immune response effectively. VLPs can act as adjuvant by regulating dendritic cells. Other adjuvant or polypeptide can be integrated into VLPs to construct chimeric vaccines. With the capability of packaging nucleic acid or other small molecules, VLPs can be used for vehicles to deliver these substances under suitable conditions. VLPs can substitute natural virus in immunology assay.

摘要

病毒样颗粒（VLPs）在结构上模拟真实病毒，但不含病毒基因组。VLPs技术在病毒组装和病毒形态多样性等基础研究中发挥着重要作用。由于具有特殊的免疫学特性，VLPs疫苗能有效诱导免疫反应。VLPs可通过调节树突状细胞发挥佐剂作用。其他佐剂或多肽可整合到VLPs中构建嵌合疫苗。凭借包装核酸或其他小分子的能力，VLPs可在合适条件下用作递送这些物质的载体。VLPs可在免疫学检测中替代天然病毒。