易于制备 3-取代苯并异噻唑从 o-巯基酰基苯甲酮。
Facile preparation of 3-substituted benzisothiazoles from o-mercaptoacylphenones.
机构信息
Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
出版信息
Org Lett. 2010 Feb 19;12(4):752-4. doi: 10.1021/ol9028447.
PMID:20078088
Abstract
A synthesis of 3-substituted benzisothiazoles starting from readily available o-mercaptoacylphenones is presented. The key cyclization step features a mild S-nitrosation and its succeeding intramolecular aza-Wittig reaction leading to the construction of the title compounds.
摘要
本文介绍了一种从易得的邻巯基酰基苯甲酮出发合成 3-取代苯并异噻唑的方法。关键的环化步骤涉及温和的 S-亚硝化反应及其后续的分子内氮杂-Wittig 反应，从而构建了标题化合物。
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