Li Bai-zhou, Lu Hong-fen, Sheng Wei-qi, Shi Da-ren
Department of Pathology, Cancer Hospital of Fudan University, Shanghai 200032, China.
Zhonghua Bing Li Xue Za Zhi. 2009 Nov;38(11):765-8.
To investigate the difference of the prevalence of t(11;18)(q21;q21)/API2-MALT1 fusion gene between gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B cell lymphoma (DLBCL).
A total of 57 cases gastrointestinal MALT lymphomas (38 gastric and 19 intestinal lymphomas), 32 DLBCL (28 gastric and 4 intestinal lymphomas) and 7 cases gastric DLBCL accompanied MALT lymphoma were collected from the Cancer Hospital of Fudan University. API2-MALT1 fusion gene was detected by fluorescent in situ hybridization (FISH) using both dual fusion translocation and break apart probes.
Among gastrointestinal MALT lymphomas, API2-MALT1 fusion gene was found in 12 of 57 cases (21.1%, 10 gastric and 2 intestinal lymphomas). In contrast, the fusion gene was not found in all 32 DLBCL and 7 gastric DLBCL with MALT lymphoma component. There was statistical significant difference between two groups (chi(2) = 9.383, P = 0.001).
API2-MALT1 fusion gene is a distinctive genetic aberration in MALT lymphomas, and is not present in DLBCL. The findings suggest that gastrointestinal tract MALT lymphomas with API2-MALT1 fusion gene may not transform into DLBCL, which may represent primary lymphoma or transformed API2-MALT1 negative MALT lymphomas.
探讨胃肠道黏膜相关淋巴组织（MALT）淋巴瘤与弥漫性大B细胞淋巴瘤（DLBCL）中t(11;18)(q21;q21)/API2-MALT1融合基因的发生率差异。
收集复旦大学附属肿瘤医院57例胃肠道MALT淋巴瘤（38例胃淋巴瘤和19例肠淋巴瘤）、32例DLBCL（28例胃淋巴瘤和4例肠淋巴瘤）以及7例伴有MALT淋巴瘤成分的胃DLBCL。采用双融合易位探针和断裂探针，通过荧光原位杂交（FISH）检测API2-MALT1融合基因。
在胃肠道MALT淋巴瘤中，57例中有12例（21.1%，10例胃淋巴瘤和2例肠淋巴瘤）检测到API2-MALT1融合基因。相比之下，所有32例DLBCL以及7例伴有MALT淋巴瘤成分的胃DLBCL中均未检测到该融合基因。两组间差异具有统计学意义（χ(2)=9.
