[上颌骨恶性肿瘤术后¹²⁵I放射性粒子组织间插植近距离治疗的技术与剂量学评估]
[The technic and dose evaluation of postoperative (125)I radioactive seeds brachytherapy for malignant tumors of maxilla].
作者信息
Huang Ming-wei, Tong Dai, Zhang Jie, Zhang Hong-zhi, Zhang Jian-guo, Yu Guang-yan
机构信息
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China.
出版信息
Zhonghua Kou Qiang Yi Xue Za Zhi. 2009 Sep;44(9):517-9.
OBJECTIVE
To evaluate the technique and effect of treating malignant tumors of maxilla with postoperative brachytherapy by digital model obturators containing (125)I radioactive seeds.
METHODS
Four patients with adnoid cystic carcinomas and two with squamous cell carcinomas in the maxilla were included in this study. All patients accepted (125)I seeds implantation after operation, and wore digital model obturators containing (125)I seeds. The prescription dose was 80 Gy. All patients were followed up every 2 months after treatment.
RESULTS
The total number of seeds used in these six patients was 189, and 105 seeds were contained in obturators. Radioactive seeds and doses distributed very well as designed in all patients. No tumors recurred after follow up of 12-16 months and there were no severe complications.
CONCLUSIONS
It's an effective way to treat malignant tumors with positive excision margin in the maxilla by brachytherapy using digital model obturators which contain (125)I radioactive seeds.
目的
评估采用含¹²⁵I放射性粒子的数字化模型赝复体进行术后近距离放疗治疗上颌骨恶性肿瘤的技术及效果。
方法
本研究纳入4例上颌骨腺样囊性癌患者和2例上颌骨鳞状细胞癌患者。所有患者术后均接受¹²⁵I粒子植入，并佩戴含¹²⁵I粒子的数字化模型赝复体。处方剂量为80 Gy。治疗后所有患者每2个月随访1次。
结果
这6例患者共使用粒子189枚，其中赝复体内含105枚。所有患者放射性粒子及剂量分布均符合设计要求。随访12 - 16个月，无肿瘤复发，未出现严重并发症。
结论
采用含¹²⁵I放射性粒子的数字化模型赝复体进行近距离放疗是治疗上颌骨手术切缘阳性恶性肿瘤的有效方法。
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