van Bel F, Guit G L, Schipper J, van de Bor M, Baan J
Department of Pediatrics, University Hospital of Leiden, The Netherlands.
J Pediatr. 1991 Apr;118(4 Pt 1):621-6. doi: 10.1016/s0022-3476(05)83391-8.
Renal dysfunction has been recognized as an adverse effect of indomethacin treatment and is probably secondary to impairment of renal blood flow. We therefore evaluated renal artery blood flow velocity in 15 premature infants with a symptomatic ductus arteriosus before and during the first 12 hours after a single intravenous dose of 0.1 mg/kg of indomethacin. Renal artery blood flow velocity was measured serially by color-Doppler flow imaging and used as a qualitative measure of true renal blood flow. Indomethacin administration led to a sharp decrease in peak systolic flow velocity and temporal mean flow velocity of the renal artery. This effect was maximal at 10 minutes after indomethacin dosing; the flow velocities showed a slow recovery, reaching baseline values again at 2 hours after indomethacin dosing. We conclude that indomethacin can affect renal blood supply in the premature infant for a period of at least 1 hour after indomethacin treatment.
肾功能不全已被认为是吲哚美辛治疗的一种不良反应，可能继发于肾血流量受损。因此，我们评估了15例有症状动脉导管未闭的早产儿在单次静脉注射0.1mg/kg吲哚美辛之前及之后12小时内肾动脉血流速度。通过彩色多普勒血流成像连续测量肾动脉血流速度，并将其用作真实肾血流量的定性指标。给予吲哚美辛导致肾动脉收缩期峰值流速和时间平均流速急剧下降。这种效应在吲哚美辛给药后10分钟时最大；流速显示缓慢恢复，在吲哚美辛给药后2小时再次达到基线值。我们得出结论，吲哚美辛治疗后至少1小时内可影响早产儿的肾血液供应。
